Name: Dynamic Human Stomach(Intestine)Extracorporeal digestive system

English name:in vitroDynamicHumanStomach(Intestine)Digestive System

Brand: Xiaodong YijianXiao Dong Pro-health

model:DIVHS(I)-IV

DIVHS(I)-IVIntroduction to the dynamic human stomach (intestine) in vitro digestive system

The dynamic human stomach (intestine) in vitro digestive system simulates the human gastrointestinal digestion process, simulating in vivo digestion and absorption under in vitro conditions，In vitro models used for predicting or evaluating the digestibility, bioavailability, release kinetics, and structural changes of compounds.Optional small and large intestine components are available.

The in vitro digestive system can completely or partially replace in vivo experiments, with advantages such as reducing costs and time, improving experimental reproducibility and accuracy, and being manually monitored.The in vitro digestive system can be widely used in food nutrition, functional active substance metabolism research, drug release kinetics research, probiotics and prebiotics, food toxicology research, etc.

DIVHS(I)-IVPrinciple of dynamic human stomach (intestine) in vitro digestive system

Xiaodong Yijian believes that the scale and characteristics of digestive systems vary among different species, and the same speciesThe 'white mouse' cannot meet the requirements of different biological experiments.

Quasi realistic in vitro simulated digestive system: simulate the morphology of digestive organs as realistically as possible/anatomic structure/Sports and biochemical environment.

“Quasi true”The in vitro digestion model should not only simulate the physical movement and chemical conditions within the gastrointestinal tract, but also provide the true morphology of the gastrointestinal tract.

(Chen, X.D. International Congress on Food Engineering and Technology. Bangkok, Thailand, 2012)

DIVHS(I)-IVAdvantages of Dynamic Human Gastrointestinal Digestive System Products in vitro

1. Unique and authentic in vitro simulated digestive system:

ØMorphological biomimetics

ØBiomimetic anatomy structure

ØDynamics biomimetics

ØbiochemistryEnvironmental Bionics

ØThe results of in vitro experiments are close to those of real in vivo experiments

2. Software full control, unmanned operation;

3. Good repeatability, convenient sampling, and online measurement;

4. Can be removed from different parts of the digestive system at any operating time;

5. Personalized customization: You can choose to use one or more of them in series or even parallel according to your actual needs. Splicing components include oral cavity, stomach, small intestine, and large intestineIntestine;

6.After sales support: A complete solution for simulating the digestive system in vitro: Application engineers can guide students throughout the experiment until they can independently get started;24Hourly phone response,365All day service.

DIVHS(I)-IVEffectiveness experiment

DIVHS(I)-IVApplication of dynamic human stomach (intestine) in vitro digestive system

The in vitro digestive system can be widely used in food nutrition, functional active substance metabolism research, drug release kinetics research, probiotics and prebiotics, food toxicology research, and large intestine fermentation，Animal nutrition、Animal digestion and feed research, etc.

The company customizes, scientifically plans, and provides professional in vitro digestion solutions for customers. We can customize human stomach models, mouse stomach models, cow stomach models, pig stomach models, large intestine fermentation models, etc. according to customer needs.

Application areas:

Fat metabolism

protein metabolism

carbohydrate

Polysaccharide metabolism

Starch digestibility

Food glycemic index

Functional components

Microbial fermentation

Probiotic fermentation

Heavy metal impact

Fungal toxins, etc

Animal nutrition

DIVHS(I)-IVDynamic human stomach (intestine) in vitro digestive system users

DIVHS(I)-IVTechnical parameters of dynamic human stomach (intestine) in vitro digestive system(Partial)

1Touch screen operation，PLCcontrolSystem.

2The compression and peristaltic frequency of the human stomach is1-15cpm Continuously adjustable.

3The peristaltic frequency of the duodenum is1-40cpm Continuously adjustable.

4Small intestinal peristalsis propulsion speed0-3 cm/sContinuously adjustable.

5Large intestine peristalsis propulsion speed0-8 cm/hContinuously adjustable.

DIVHS(I)-IVDynamic human stomach (intestine) in vitro digestive system publishedArticle (Part)

[1] Chen L, Jayemanne A, Chen X D. Venturing intoin vitrophysiological upper GI system focusing on the motility effect provided by a mechanised rat stomach model[J]. Food Digestion, 2013, 4(1):36-48.

Focusing on the dynamic effects provided by the mechanical rat stomach model, this study aims to investigate the physiological upper gastrointestinal system in vitro

[2] Chen L, Wu X, Chen X D. Comparison between the digestive behaviors of a newin vitrorat soft stomach model with that of thein vivoexperimentation on living rats - motility and morphological influences[J]. Journal of Food Engineering, 2013, 117(2):183-192.

Comparison of digestive behavior of a novel in vitro rat gastric soft model and the effects on motility and morphology of a live rat gastric soft model

[3] Wu P, Chen L, Wu X, et al. Digestive behaviours of large raw rice particlesin vivoandin vitrorat stomach systems[J]. Journal of Food Engineering, 2014, 142:170-178.

Digestive behavior of rat gastric system in vivo and in vitro

[4] Chen L, Xu Y, Fan T, et al. Gastric emptying and morphology of a ‘near real'in vitrohuman stomach model (RD-IV-HSM)[J]. Journal of Food Engineering, 2016, 183:1-8.

Gastric emptying and in vitro human gastric model(RD-IV-HSM)Morphological research

[5] Wu P, Deng R, Wu X, et al.In vitrogastric digestion of cooked white and brown rice using a dynamic rat stomach model[J]. Food Chemistry, 2017, 237:1065.

In vitro gastric digestion of cooked white rice and brown rice using a dynamic rat stomach model

[6] Wu P, Liao Z, Luo T, et al. Enhancement of digestibility of casein powder and raw rice particles in an improved dynamic rat stomach model through an additional rolling mechanism[J]. Journal of Food Science, 2017, 82(3).

In an improved dynamic rat stomach model, the digestibility of casein white powder and raw rice granules was increased through an additional rolling mechanism

[7] Bhattarai R R, Dhital S, Wu P, et al. Digestion of isolated legume cells in a stomach-duodenum model: three mechanisms limit starch and protein hydrolysis[J]. Food & Function, 2017, 8(7).

Digestive study of isolated leguminous cells in a gastroduodenal model: Three mechanisms limiting starch and protein hydrolysis

[8] Wu P, Bhattarai R R, Dhital S, et al. In vitro digestion of pectin- and mango-enriched diets using a dynamic rat stomach-duodenum model[J]. Journal of Food Engineering, 2017, 202:65-78.

In vitro digestion of pectin and mango rich diet using a dynamic rat gastroduodenal model

[9] Microwave pretreatment enhances the formation of cabbage sulforaphane and its bioaccessibility as shown by a novel dynamic soft rat stomach model[J]. Journal of Functional Foods, 2018, 43:186-195.

Microwave pretreatment increases the formation and bioavailability of sulforaphane in cabbage and radish

[10] Zhang X, Liao Z, Wu P, et al. Effects of the gastric juice injection pattern and contraction frequency on the digestibility of casein powder suspensions in an, in vitro, dynamic rat stomach made with a 3D printed model[J]. Food Research International, 2018, 106:495-502.

stay3DThe effect of gastric juice injection mode and contraction frequency on the digestibility of casein powder suspension in vitro dynamic rat stomach printed model

[11] Zhao B, Sun S, Lin H, et al. Physicochemical properties and digestion of the lotus seed starch-green tea polyphenol complex under ultrasound-microwave synergistic interaction[J]. Ultrasonics Sonochemistry, 2018.

ultrasonic-Lotus seed starch under microwave synergistic effect-Physical and chemical properties and digestion of green tea polyphenol complex

[12] Wang J, Wu P, Liu M H, et al. An advanced near real dynamicin vitrohuman stomach system to study gastric digestion and emptying of beef stew and cooked rice[J]. Food & Function, 2019.

An advanced in vitro human gastric system that approaches real dynamics for studying gastric digestion and emptying of stewed beef and rice